As Rena Sofer gears up to reprise her role as Lois Cerullo on General Hospital, she reflects on the significance of portraying a character that she credits with opening doors and launching her career.
After 27 years away from the General Hospital set, Sofer is set to make a much-anticipated return, as her character Lois Cerullo visits Port Charles.
Lois’ daughter, Brook Lynn Quartermaine (Amanda Setton), has been entangled in a complex storyline in Port Charles since 2019.
With a scheming grandmother and Ned Quartermaine’s (Wally Kurth) head injury leading him to believe he’s rock star Eddie Maine, the stage is set for Lois to make her return.
In a recent interview with Soap Opera Digest, Sofer shared the unexpected journey that led to her return. Frank Valentini, GH’s executive producer, reached out to her via text, sparking a conversation about her potential return.

Recalling their last meeting at a wedding in October 2021, Sofer explained how Valentini had expressed interest in bringing her back, but at the time, she was committed to her role as Quinn Fuller on The Bold and The Beautiful. With her exit from that role in 2022, the timing aligned perfectly for Lois’ return.
Sofer, eager to embrace the opportunity, expressed her excitement about reprising the character of Lois, a role she considers one of the top three in her 37-year acting career.
Her recent empty nest, following her youngest daughter’s departure for college, allowed her the time to fully immerse herself in preparing for the role.
Returning to the General Hospital set, however, stirred a mix of emotions for Sofer. Acknowledging the show’s rich history, she confessed to feeling nervous about how she would be received.
Beyond concerns about timing and line rehearsals, Sofer found herself questioning whether the cast and crew would welcome her back.
A distinctive aspect of Lois’ character is her intricate nails, a detail that Sofer emphasized in her portrayal from the beginning.
Collaborating with a professional nail artist, Amber Studer, Sofer ensured that Lois’ iconic nails matched her outfits seamlessly, just as she envisioned.
Delving into the complexities of reimagining Lois’ life after 27 years, Sofer acknowledged the challenge of filling in the gaps and understanding how Lois evolved.

Despite the focus on her character, Sofer emphasized her role in supporting the overarching stories involving Brook Lynn, Eddie Maine, and Ned.
Stepping onto the General Hospital set, Sofer felt a sense of déjà vu, especially in the Quartermaine mansion. Reflecting on the absence of key figures like Anna Lee and John Ingle, Sofer found the experience emotionally impactful.
Equally moving for Sofer was the enthusiastic reaction from fans anticipating her return. She expressed gratitude for the constant support over the past 27 years, acknowledging that the fans’ excitement fueled her own.
As Sofer’s return to General Hospital approaches on October 10, 2023, fans are left wondering about the potential impact on the Olivia-Ned relationship.
Will Lois’ return rekindle memories for Ned, and how will it affect the dynamics in Port Charles? The anticipation is palpable, and fans are encouraged to share their thoughts and predictions on social media platforms.
Rena Sofer’s return promises not only a reinvigoration of a beloved character but also a captivating addition to General Hospital’s storied legacy.